![]() ![]() Still, electrical stimulation has been demonstrated to effect persistent changes in connectivity and synaptic strength of stimulated circuits in experimental models of the intact and injured CNS. However, despite documented improvements in functional recovery from a combination of rehabilitation with neural stimulation, rehabilitation alone remains the only therapy of standard practice for chronic neural injury 4, 5, 6, 7. The concept of electrical stimulation as a potential therapy for central nervous system (CNS) trauma has gained traction in recent years. Yet, they have garnered notably less attention compared to interventions that target lower limb functions, such as standing and walking. Hand and arm recovery is the top ranked treatment priority for those suffering from cervical SCI 2, 3, thus interventions to target hand and arm recovery are of critical importance. Paralysis of the hand is a common condition following cervical spinal cord injury (SCI), brain trauma, or stroke 1. Further, electrophysiology mapping of the ventral spinal cord revealed the ventral approach was suitable to target muscle groups of the rat forelimb and, at a single electrode lead position, different stimulation protocols could be applied to achieve unique activation patterns of the muscles of the forelimb. Our approach allowed for preservation of mobility following surgery and was suitable for long term stimulation strategies in awake, freely functioning animals. We therefore designed a novel approach for epidural stimulation of the rat spinal cord using a wireless stimulation system and ventral electrode array. Penetrating wire electrodes have been explored in rodent and pig models and, while they have proven beneficial in the injured spinal cord, the negative aspects of spinal parenchymal penetration (e.g., gliosis, neural tissue damage, and obdurate inflammation) are of concern when considering therapeutic potential. Electrical stimulation of the cervical spinal cord is gaining traction as a therapy following spinal cord injury however, it is difficult to target the cervical motor region in a rodent using a non-penetrating stimulus compared with direct placement of intraspinal wire electrodes. ![]()
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